Comisión Científica del Centro de analistas del Distrito X

Bienvenida
Bienvenidos a este nuevo espacio creado especialmente para nosotros. En esta página hemos colocado links a: PubMed, el buscador más utilizado en la investigación biomédica.

Integrantes:

Dra. Graciela Cascone, Dra. Ana Paris de Baeza, Dra. Raquel Prieto, Dr. Niels Suldrup,
Dr. Juan Tentoni y Dra. Sandra Voglino

Estimados Colegas:

En el apartado correspondiente al curso de Terapia Anticoagulante se ha colocados un acceso a los archivos Power Point de las presentaciones realizadas por los docentes. Durante en los días 3, 4, 10 y 11 de Septiembre se dictará el curso: “Bioestadística con Aplicaciones al Laboratorio”. Este será el último curso programado por esta subcomisión.

Recordamos que durante los días 13 al 17 de Septiembre se realizarán las XVIII Jornadas Científicas “Dr. Juan Carlos Plunkett” del Hospital Interzonal Dr. José Penna. El tema central será “VIOLENCIA: Un enfoque integral”. Para mayor información dirigirse a: http://www.hospitalpenna.com.ar/archivos/docencia_jornadas_2010_a.html

Para esta edición ese ha seleccionado un artículo introductorio a las enfermedades de origen genético, “An introduction to genes, genome and disease” que fue publicado por el “Journal of Pathology”. Este artículo nos comenta sobre el impacto que ha tenido la Biología Molecular moderna sobre el conocimiento de las enfermedades y el entendimiento de sus procesos. Como segundo artículo seleccionado se entrega una revisión sobre Osteoporosis publicada por la revista NATURE: Gastroenterology & Hepatology. “Current Understanding of Osteoporosis Associated with Liver Disease” presenta una investigación realizada sobre la patogénesis de la Osteoporisis, el conocimiento actual sobre esta enfermedad y los avances hechos en este campo.

Se recuerda que están invitados todos los socios del CAC a formar parte de la Subcomisión Científica. Los días de reunión son los primeros viernes de cada mes, a las 13:30 hs en la Sede del CAC X Lavalle 467.

Niels Suldrup
Sub-Comisión Científica
Centro de Analistas Clínicos D X

ARTICULO

An introduction to genes, genome and disease

The human and other genome projects and subsequent resequencing programmes have provided new perspectives on the nature of the gene and how genes function. Understanding the complexity of the eukaryotic nucleus and the diversity of genetic regulatory mechanisms, including the role of non-coding RNAs, translational control mechanisms and the extraordinary prevalence of splicing, will be central to understanding how genes function, as will the recognition of gene dosage issues. This introduction to the 2010 Annual Review Issue, Genes, Genomes and Disease, provides overviews of these areas and then considers their relevance to a range of human diseases, including cardiovascular and renal disease, neural tube defects and cancer. The p53 gene is considered as an example of a massively regulated gene and the genetic perturbations in cancer are considered in a historical perspective. High-throughput genomic and transcriptomic methods have led to a paradigm shift in the way cancers are perceived and have changed the way translational research is performed. The progress in our understanding of chromosomal rearrangements in cancer, once believed to be incredibly rare events in epithelial malignancies, is discussed. The identification of low-penetrance cancer susceptibility genes through genome-wide association studies and their implications are reviewed. The contribution and limitations of expression profiling are discussed. In the last series of reviews, future challenges are addressed: the promise of synthetic lethality strategies in cancer therapy, a case for ‘systems’ approaches to genetic networks and the potential of single molecule genetic technologies. Finally, the question ‘Does massively parallel DNA resequencing signify the end of histopathology as we know it?’ is posed. Readers should find that the 2010 Annual Review Issue is an invaluable resource on contemporary genetics and its applications to understanding disease. Copyright ? 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

ARTICULO

Current Understanding of Osteoporosis Associated with Liver Disease

Osteoporosis is a common complication of many types of liver disease. Research into the pathogenesis of osteoporosis has revealed that the mechanisms of bone loss differ between different types of liver disease. This Review summarizes our current understanding of osteoporosis associated with liver disease and the new advances that have been made in this field. The different mechanisms by which cholestatic and parenchymal liver disease can lead to reduced bone mass, the prevalence of osteopenia and osteoporosis in patients with early and advanced liver disease, and the influence of osteoporotic fractures on patient survival are discussed along with the advances in our understanding of the molecular pathways associated with bone loss. The role of the CSF1–RANKL system and that of the liver molecule, oncofetal fibronectin, a protein that has traditionally been viewed as an extracellular matrix protein are also discussed. The potential impact that these advances may have for the treatment of osteoporosis associated with liver disease is also reviewed.