Bienvenida

Bienvenida
Bienvenidos a este nuevo espacio creado especialmente para nosotros. En esta página hemos colocado links a: PubMed, el buscador más utilizado en la investigación biomédica.
Temas de interés

Asociacion Argentina de Microbiología
Guia de enfermedades raras

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Enlaces
Sub Comisión Científica

Integrantes:

Dra. Graciela Cascone, Dra. Ana Paris de Baeza, Dra. Raquel Prieto, Dr. Niels Suldrup,
Dr. Juan Tentoni y Dra. Sandra Voglino

Estimados Colegas

En el marco de los eventos organizados por el 50° Aniversario del Centro de Analistas Clínicos Distrito X, brindaremos una charla abierta a comunidad, a cargo del Dr. Sergio García Ercoli sobre el tema Hipertensión y Embarazo, se realizará en el Auditorio de OSDE, Rodríguez 362, el jueves 8 de Septiembre, a las 19:00 hs.
Durante los dos días siguientes se ofrecerá un curso para profesionales sobre el mismo tema a cargo de docentes de la Fundación Wiener. Este curso será sin cargo para todos los participantes, quienes se deberán inscribir con anticipación debido al cupo asignado para el auditorio del CAC.
Para esta edición hemos seleccionado son siguientes artículos, ambos artículos son un valioso aporte al Curso de este mes.

Recordamos que  durante los días 28 y 29 de Octubre se llevarán a cabo  las XVI Jornadas de Residentes Bioquímicos de la Provincia de Buenos Aires. Ya está a disposición el Cronograma de las actividades que se desarrollarán.

           
Dr. Niels Suldrup
Sub-Comisión Científica
Centro de Analistas Clínicos D X

Artículos seleccionados

ARTÍCULO
Abstract | The lipoprotein HDL has two important roles: first, it promotes reverse cholesterol transport, and second, it modulates inflammation. Epidemiological studies show that HDL-cholesterol levels are inversely correlated with the risk of cardiovascular events. However, many patients who experience a clinical event have normal, or even high, levels of HDL cholesterol. Measuring HDL-cholesterol levels provides information about the size of the HDL pool, but does not predict HDL composition or function. The main component of HDL, apolipoprotein A-I (apo A-I), is largely responsible for reverse cholesterol transport through the macrophage ATP-binding cassette transporter ABCA1. Apo A-I can be damaged by oxidative mechanisms, which render the protein less able to promote cholesterol efflux. HDL also contains a number of other proteins that are affected by the oxidative environment of the acute-phase response. Modification of the protein components of HDL can convert it from an anti-inflammatory to a proinflammatory particle. Small peptides that mimic some of the properties of apo A-I have been shown in preclinical models to improve HDL function and reduce atherosclerosis without altering HDL-cholesterol levels. Robust assays to evaluate the function of HDL are needed to supplement the measurement of HDL-cholesterol levels in the clinic.


ARTÍCULO
Abstract | Besides measuring blood pressure and glucose levels, assessing the lipid spectrum is the method most commonly used to identify individuals at high risk of cardiovascular disease (CVD), as well as those who are likely to benefit most from lipid-lowering therapy. Although lowering LDL-cholesterol levels is the primary target of therapy in most clinical guidelines, accumulating evidence indicates that other lipoprotein–lipid measurements could provide a predictive value over and above that of LDL-cholesterol levels. For example, individuals treated with statins who achieve low LDL-cholesterol levels, but have high concentrations of either non-HDL cholesterol or apolipoprotein (apo) B, remain at increased cardiovascular risk. Similarly, individuals with low levels of either HDL cholesterol or apo A-I are also likely to experience cardiovascular events, despite having normal LDL-cholesterol levels. The residual cardiovascular risk, beyond that characterized by LDL-cholesterol levels alone, is exacerbated by physical inactivity and abdominal obesity, which are both increasingly prevalent risk factors for CVD. In this Review, we discuss the measurement of various lipoprotein–lipid parameters for the prediction of CVD risk, and their importance in identifying those patients who are likely to benefit from lipid-lowering therapy. The impact of recent studies on clinical guidelines is also considered.


Eventos

CURSOS
15 y 16 de Abril


CURSO
Artritis séptica Infecciones asociadas a prótesis articulares Fractura expuesta Espondilodiscitis Osteomielitis Infección de partes blandas
Métodos diagnósticos de infecciones protésicas más comunes
Presentación de casos clínicos


CURSOS

Se suspende el curso por razones ajenas a la Subcomisión Científica.


CURSOS
19 y 20 de Agosto


CURSO
Ver temario


CURSOS
20 y 21 de Mayo


CURSOS
9 y 10 de Septiembre